Mesenchymal stem cells promote glioma neovascularization in vivo by fusing with cancer stem cells.

ABSTRACT:

Background and objective

Tumor angiogenesis is vital for tumor growth. Recent evidence indicated that bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to tumor sites and exert critical effects on tumor growth through direct and/or indirect interactions with tumor cells. However, the effect of BMSCs on tumor neovascularization has not been fully elucidated. This study aimed to investigate whether fusion cells from glioma stem cells and BMSCs participated in angiogenesis.

Methods

SU3-RFP cells were injected into the right caudate nucleus of NC-C57Bl/6 J-GFP nude mice, and the RFP+/GFP+ cells were isolated and named fusion cells. The angiogenic effects of SU3-RFP, BMSCs and fusion cells were compared in vivo and in vitro.

Results

Fusion cells showed elevate

SUBMITTER: Sun C 

PROVIDER: S-EPMC6925905 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature