Gut Microbiota in Alcoholic Hepatitis is Disparate from Those in Acute Alcoholic Pancreatitis and Biliary Disease.

ABSTRACT:

Background

Alcoholic hepatitis (AH) is associated with gut dysbiosis. Comparative gut microbial profiles of acute alcoholic pancreatitis (AAP) and acute biliary disease (ABD) are not demonstrated. We aimed to compare gut microbiota of AH, AAP, and ABD patients with each other and with their respective healthy controls (HCs).

Methods

From December 2016 to September 2017, consecutive patients with AH, AAP, and ABD (acute cholecystitis, acute biliary pancreatitis, and choledocholithiasis with cholangitis) were included in the study. Qualitative and functional stool microbiota comparative analysis was performed between groups, with AH as the reference comparator.

Results

Of 3564, 882, and 224 patients with liver disease, pancreatic disease, and biliary disease, respective

SUBMITTER: Philips CA 

PROVIDER: S-EPMC6926215 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature