Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies.

ABSTRACT:

Purpose

Postischemic reperfusion injury may exacerbate cerebral damage and capillary dysfunction, leading to brain edema (BE), hemorrhagic transformation (HT), necrosis, and injury from free radicals with subsequent infarct growth (IG). Several plasmatic biomarkers involved in the ischemic cascade have been studied in relation to radiological and clinical outcomes of reperfusion injury in ischemic stroke with heterogeneous results. This article provides a brief overview of the contribution of circulating biomarkers to the pathophysiology of parenchymal damage in ischemic stroke patients treated with revascularization therapies.

Methods

We included full reports with measurements of plasma markers in patients with acute ischemic stroke treated with revascularization therapies.

SUBMITTER: Piccardi B 

PROVIDER: S-EPMC6931146 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature