Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis.

ABSTRACT: In animals, the brain regulates feeding behavior in response to local energy demands of peripheral tissues, which secrete orexigenic and anorexigenic hormones. Although skeletal muscle is a key peripheral tissue, it remains unknown whether muscle-secreted hormones regulate feeding. In Drosophila, we found that decapentaplegic (dpp), the homolog of human bone morphogenetic proteins BMP2 and BMP4, is a muscle-secreted factor (a myokine) that is induced by nutrient sensing and that circulates and signals to the brain. Muscle-restricted dpp RNAi promotes foraging and feeding initiation, whereas dpp overexpression reduces it. This regulation of feeding by muscle-derived Dpp stems from modulation of brain tyrosine hydroxylase (TH) expression and dopamine

SUBMITTER: Robles-Murguia M 

PROVIDER: S-EPMC6938663 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature