Vitamin D Inhibition of TRPV5 Expression During Osteoclast Differentiation.

ABSTRACT:

Background

Vitamin D is an important steroid that can regulate bone metabolism including osteoclast (OC) differentiation. Transient receptor potential cation channel subfamily V member 5 (TRPV5), is a calcium channel protein involved in OC differentiation. However, the impact of vitamin D on TRPV5 expression during OC differentiation is not clear.

Objectives

To determine if 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃) regulates the expression of TRPV5 during OC differentiation.

Methods

Bone marrow mononuclear macrophage (BMMs) were induced to differentiate into OC with or without treatment with 10 nM 1,25(OH)₂D₃. The expression levels of vitamin D receptor (VDR) and TRPV5 were examined. The expression of several OC markers, includ

SUBMITTER: Gu J 

PROVIDER: S-EPMC6948119 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature