Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial.

ABSTRACT:

Background

Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis.

Methods

LOVIT (Lessening Organ dysfunction with VITamin C) is a multicenter, parallel-group, blinded (participants, clinicians, study personnel, Steering Committee members, data analysts), superiority RCT (minimum n = 800). Eligible patients have sepsis as the diagnosis for admission to the intensive care unit (ICU) and are receiving vasopressors. Those admitted

SUBMITTER: Masse MH 

PROVIDER: S-EPMC6950903 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature