Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.

ABSTRACT:

Background

We hypothesized that the risk of colorectal cancer in night-shift workers might be different according to insulin receptor substrate status.

Methods

Among 77,470 eligible women having night work assessed in the Nurses' Health Study, we documented a total of 1,397 colorectal cancer cases, of which 304 or 308 had available data on IRS1 and IRS2, respectively. We used duplication-method Cox proportional hazards regression analysis for competing risks to calculate HRs and 95% confidence intervals (CI) for each colorectal cancer subtype. We measured tumor IRS1 or IRS2 expression by immunohistochemistry (IHC).

Results

Compared with women who never worked night shifts, those working ≥15 years night shifts had a marginal trend of increas

SUBMITTER: Shi Y 

PROVIDER: S-EPMC6954315 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature