Ontology highlight
ABSTRACT:
SUBMITTER: Galupa R
PROVIDER: S-EPMC6964159 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20191120 2
cis-Regulatory communication is crucial in mammalian development and is thought to be restricted by the spatial partitioning of the genome in topologically associating domains (TADs). Here, we discovered that the Xist locus is regulated by sequences in the neighboring TAD. In particular, the promoter of the noncoding RNA Linx (LinxP) acts as a long-range silencer and influences the choice of X chromosome to be inactivated. This is independent of Linx transcription and independent of any effect o ...[more]