Dataset Information

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

ABSTRACT:

Objectives

To estimate the proportion of the Canadian population that is more susceptible to adverse effects of ozone (O₃) and fine particle (PM_2.5) air pollution exposure and how this varies by health region alongside ambient concentrations of O₃ and PM_2.5.

Methods

Using data from the census, the Canadian Community Health Survey, vital statistics and published literature, we generated cross-sectional estimates for 2014 of the proportions of the Canadian population considered more susceptible due to age, chronic disease, pregnancy, outdoor work, socio-economic status, and diet. We also estimated 2010-2012 average concentrations of O₃ and PM_2.5. Analyses were conducted nationally and for 110 health regions.

Results

Restrictive criteria (age < 10 or ≥ 75; asthma, chronic obstructive pulmonary disease, heart disease, or diabetes; pregnancy) suggested that approximately one third of the Canadian population is more susceptible, while inclusive criteria (restrictive plus age 10-19 and 65-74, outdoor work, less than high school education, low vitamin C intake) increased this proportion to approximately two thirds. Across health regions, estimates ranged from 24.4% to 41.2% (restrictive) and 61.2% to 87.0% (inclusive). Ten health regions were in the highest quartile of both population susceptibility and O₃ or PM_2.5 concentrations, all of which were outside major urban centres.

Conclusions

A substantial proportion of the Canadian population exhibits at least one risk factor that increases their susceptibility to adverse effects of O₃ and PM_2.5 exposure. Both risk communication and management interventions need to be increasingly targeted to regions outside large urban centres in the highest quartiles of both susceptibility and exposure.

SUBMITTER: Stieb DM

PROVIDER: S-EPMC6964403 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

Stieb David M DM Yao Jiayun J Henderson Sarah B SB Pinault Lauren L Smith-Doiron Marc H MH Robichaud Alain A van Donkelaar Aaron A Martin Randall V RV Ménard Richard R Brook Jeffrey R JR

Canadian journal of public health = Revue canadienne de sante publique 20190107 2

<h4>Objectives</h4>To estimate the proportion of the Canadian population that is more susceptible to adverse effects of ozone (O<sub>3</sub>) and fine particle (PM<sub>2.5</sub>) air pollution exposure and how this varies by health region alongside ambient concentrations of O<sub>3</sub> and PM<sub>2.5</sub>.<h4>Methods</h4>Using data from the census, the Canadian Community Health Survey, vital statistics and published literature, we generated cross-sectional estimates for 2014 of the proportion ...[more]

PMID: 30617991

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Project description:BackgroundEpidemiological studies report fairly consistent associations between various air pollution metrics and autism spectrum disorder (ASD), with some elevated risks reported for different prenatal and postnatal periods.ObjectivesTo examine associations between ASD and ambient fine particulate matter (PM2.5) and ozone concentrations during the prenatal period through the second year of life in a case-control study.MethodsASD cases (n = 428) diagnosed at Cincinnati Children's Hospital Medical Center were frequency matched (15:1) to 6420 controls from Ohio birth records. We assigned daily PM2.5 and ozone estimates for 2005-2012 from US EPA's Fused Air Quality Surface Using Downscaling model to each participant for each day based on the mother's census tract of residence at birth. We calculated adjusted odds ratios (aORs) using logistic regression across continuous and categorical exposure window averages (trimesters, first and second postnatal years, and cumulative measure), adjusting for maternal- and birth-related confounders, both air pollutants, and multiple temporal exposure windows.ResultsWe detected elevated aORs for PM2.5 during the 2nd trimester, 1st year of life, and a cumulative period from pregnancy through the 2nd year (aOR ranges across categories: 1.41-1.44, 1.54-1.84, and 1.41-1.52 respectively), and for ozone in the 2nd year of life (aOR range across categories: 1.29-1.42). Per each change in IQR, we observed elevated aORs for ozone in the 3rd trimester, 1st and 2nd years of life, and the cumulative period (aOR range: 1.19-1.27) and for PM2.5 in the 2nd trimester, 1st year of life, and the cumulative period (aOR range: 1.11-1.17).DiscussionWe saw limited evidence of linear exposure-response relationships for ASD with increasing air pollution, but the elevated aORs detected for PM2.5 in upper exposure categories and per IQR unit increases were similar in magnitude to those reported in previous studies, especially for postnatal exposures.

Project description:BackgroundAir pollution is linked to neurodevelopmental delays, but its association with longitudinal changes in brain network development has yet to be investigated. We aimed to characterize the effect of PM2.5, O3, and NO2 exposure at ages 9-10 years on changes in functional connectivity (FC) over a 2-year follow-up period, with a focus on the salience (SN), frontoparietal (FPN), and default-mode (DMN) brain networks as well as the amygdala and hippocampus given their importance in emotional and cognitive functioning.MethodsA sample of children (N = 9,497; with 1-2 scans each for a total of 13,824 scans; 45.6% with two brain scans) from the Adolescent Brain Cognitive Development (ABCD) Study® were included. Annual averages of pollutant concentrations were assigned to the child's primary residential address using an ensemble-based exposure modeling approach. Resting-state functional MRI was collected on 3T MRI scanners. First, developmental linear mixed-effect models were performed to characterize typical FC development within our sample. Next, single- and multi-pollutant linear mixed-effect models were constructed to examine the association between exposure and intra-network, inter-network, and subcortical-to-network FC change over time, adjusting for sex, race/ethnicity, income, parental education, handedness, scanner type, and motion.ResultsDevelopmental profiles of FC over the 2-year follow-up included intra-network integration within the DMN and FPN as well as inter-network integration between the SN-FPN; along with intra-network segregation in the SN as well as subcortical-to-network segregation more broadly. Higher PM2.5 exposure resulted in greater inter-network and subcortical-to-network FC over time. In contrast, higher O3 concentrations resulted in greater intra-network, but less subcortical-to-network FC over time. Lastly, higher NO2 exposure led to less inter-network and subcortical-to-network FC over the 2-year follow-up period.ConclusionTaken together, PM2.5, O3, and NO2 exposure in childhood relate to distinct changes in patterns of network maturation over time. This is the first study to show outdoor ambient air pollution during childhood is linked to longitudinal changes in brain network connectivity development.

Dataset Information

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

Objectives

Methods

Results

Conclusions

Publications

Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.

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