Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.

ABSTRACT: BACKGROUND:Generalized gingival fibromatosis is characterized by a progressive overgrowth of the gingiva, which can be caused by a variety of factors. According to these factors, it can be defined as hereditary gingival fibromatosis, non-familial gingival fibromatosis or drug-induced gingival fibromatosis. Non-familial gingival fibromatosis is a rare entity that needs to be documented. CASE PRESENTATION:Here, we describe two cases of Chinese non-familial gingival fibromatosis. A six-year-old girl and a five-year-old boy presented with generalized gingival overgrowth. Clinical appearance, histological examination, and family history lead to the diagnosis of non-familial gingival fibromatosis. Real time PCR was performed to examine the expression of the ?2-integrin gene, ITGA2, and identified decreased expression of ITGA2 in the gingiva of patients compared to both their parents and healthy volunteers. This is the first evidence that suggests a role for ITGA2 in non-familial gingival fibromatosis. CONCLUSION:Our findings provide evidence that altered cell-matrix interactions via collagen receptors, such as ?2-integrin, may play a role in non-familial gingival fibromatosis. Thus, targeting collagen receptors might be an attractive target for the treatment of gingival fibromatosis.

SUBMITTER: Liu C 

PROVIDER: S-EPMC6965286 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature