ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling.

ABSTRACT: Increasing evidence has indicated that the disorganized expression of certain genes promotes tumour progression. In this study, we elucidate the potential key differentially expressed genes (DEGs) between glioblastoma (GBM) and normal brain tissue by analysing three different mRNA expression profiles downloaded from the Gene Expression Omnibus (GEO) database. DEGs were sorted, and key candidate genes and signalling pathway enrichments were analysed. In our analysis, the highest fold change DEG was found to be abnormal spindle-like microcephaly associated (ASPM). The ASPM expression pattern from the database showed that it is highly expressed in GBM tissue, and patients with high expression of ASPM have a poor prognosis. Moreover, ASPM showed aberrantly high expression in GBM cell lines. Lo

SUBMITTER: Chen X 

PROVIDER: S-EPMC6977704 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature