Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.

ABSTRACT:

Background

Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development.

Patients and methods

We explored possible associations between Cox-2 polymorphisms and risk of adenoma development in an African American case-control study comprising 72 cases of advanced adenomas and 146 polyp-free controls. An exhaustive approach of genotyping 13 haplotype-tagging SNPs (ht SNPs) distributed over the entire COX-2 gene was used.

Results

Statistically significant inverse associations were observed between the heterozygous genotypes at the 5229 G>T polymorphism in intron 5 [odds ratio (OR)=0.42; confidence interval (CI)=0.19-0.92; p=0.03] and at the 10935 A>G polymorphism in the 3' flanking region d

SUBMITTER: Ashktorab H 

PROVIDER: S-EPMC6980310 | biostudies-literature | 2008 Sep-Oct

REPOSITORIES: biostudies-literature