Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice.

ABSTRACT:

Objective

Previous studies have reported that individuals with obesity have reduced taste perception, but the relationship between obesity and taste is poorly understood. Earlier work has demonstrated that diet-induced obesity directly impairs taste. Currently, it is not clear whether these changes to taste are due to obesity or to the high-fat diet exposure. The goal of the current study was to determine whether diet or excess weight is responsible for the taste deficits induced by diet-induced obesity.

Methods

C57BL/6 mice were placed on either high-fat or standard chow in the presence or absence of captopril. Mice on captopril did not gain weight when exposed to a high-fat diet. Changes in the responses to different taste stimuli were evaluated using live cell imaging, br

SUBMITTER: Ahart ZC 

PROVIDER: S-EPMC6981059 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature