Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study.

ABSTRACT:

Background

Multiple sclerosis is often associated with unemployment. The contribution of grey matter atrophy to unemployment is unclear.

Objectives

To identify magnetic resonance imaging biomarkers of grey matter and clinical symptoms associated with unemployment in multiple sclerosis patients.

Methods

Demographic, clinical data and 1.5 T magnetic resonance imaging scans were collected in 81 patients at the time of inclusion and after 5 and 10 years. Global and tissue-specific volumes were calculated at each time point. Statistical analysis was performed using a mixed linear model.

Results

At baseline 31 (38%) of the patients were unemployed, at 5-year follow-up 44 (59%) and at 10-year follow-up 34 (81%) were unemployed. The unemployed patients had significantl

SUBMITTER: Jacobsen C 

PROVIDER: S-EPMC6987492 | biostudies-literature | 2020 Jan-Mar

REPOSITORIES: biostudies-literature