Methods and Challenges in a Cohort Study of Infants and Toddlers With Craniofacial Microsomia: The Clock Study.

ABSTRACT:

Objective

The Craniofacial microsomia: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK) study is a longitudinal cohort study of neurobehavioral outcomes in infants and toddlers with craniofacial microsomia (CFM). In this article, we review the data collection and methods used to characterize this complex condition and describe the demographic and clinical characteristics of the cohort.

Setting

Craniofacial and otolaryngology clinics at 5 study sites.

Participants

Infants with CFM and unaffected infants (controls) ages 12 to 24 months were recruited from the same geographical regions and followed to age 36 to 48 months.

Methods

Phenotypic, neurodevelopmental, and facial expression assessments were completed during the first and third waves of data coll

SUBMITTER: Luquetti DV 

PROVIDER: S-EPMC6996714 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature