Comparison of DNA methylation profiles from saliva in Coeliac disease and non-coeliac disease individuals.

ABSTRACT:

Background

Coeliac disease (CD) is a autoimmune disease characterised by mucosal inflammation in the small intestine in response to dietary gluten. Genetic factors play a key role with CD individuals carrying either the HLA-DQ2 or HLA-DQ8 haplotype, however these haplotypes are present in half the general population making them necessary but insufficient to cause CD. Epigenetic modifications, including DNA methylation that can change in response to environmental exposure could help to explain how interactions between genes and environmental factors combine to trigger disease development. Identifying changes in DNA methylation profiles in individuals with CD could help discover novel genomic regions involved in the onset and development of CD.

Methods

The Illumina InfiniumMet

SUBMITTER: Hearn NL 

PROVIDER: S-EPMC6998322 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature