Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy.

ABSTRACT: The etiology of respiratory allergies (RA) can be partly explained by DNA methylation changes caused by adverse environmental and lifestyle factors experienced early in life. Longitudinal, prospective studies can aid in the unravelment of the epigenetic mechanisms involved in the disease development. High compliance rates can be expected in these studies when data is collected using non-invasive and convenient procedures. Saliva is an attractive biofluid to analyze changes in DNA methylation patterns. We investigated in a pilot study the differential methylation in saliva of RA (n = 5) compared to healthy controls (n = 5) using the Illumina Methylation 450K BeadChip platform. We evaluated the results against the results obtained in mononuclear blood cells from the same individuals. Differe

SUBMITTER: Langie SA 

PROVIDER: S-EPMC4801358 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature