Ontology highlight
ABSTRACT:
SUBMITTER: Schantl AE
PROVIDER: S-EPMC7002685 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200205 1
Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors, among which 4,6-di-O-(methoxy-diethyleneglycol)-myo-inositol-1,2,3,5-tetrakis(phosphate), (OEG<sub>2</sub>)<sub>2</sub>-IP4, displays increased in vitro activity, as well as more favorable pharmacokinetic and safety p ...[more]