Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat-shock proteins (HSPs). Current study assessed the frequency and association of HSP70-hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis.

Methods

This polymorphism was selected through bioinformatics analyses and identified by PCR-RFLP method.

Results

Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while

SUBMITTER: Moniruzzaman M 

PROVIDER: S-EPMC7005638 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature