Proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryotherapy and irradiation.

ABSTRACT: Biological reconstruction of allografts and recycled autografts have been widely implemented in high-grade osteogenic sarcoma. For treating tumor-bearing autografts, extracorporeal irradiation (ECIR) and liquid nitrogen (LN) freezing techniques are being used worldwide as a gold standard treatment procedure. Both the methods aim to eradicate the tumor cells from the local recurrence and restore the limb function. Therefore, it is essential and crucial to find, and compare the alterations at molecular and physiological levels of the treated and untreated OGS recycled autografts to obtain valuable clinical information for better clinical practice. Thus, we aimed to investigate the significantly expressed altered proteins from ECIR-and cryotherapy/freezing- treated OGS (n = 12) were compared

SUBMITTER: Madda R 

PROVIDER: S-EPMC7005698 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature