Hydroxychloroquine may reduce risk of Pneumocystis pneumonia in lupus patients: a Nationwide, population-based case-control study.

ABSTRACT: BACKGROUND:Pneumocystis pneumonia (PCP) is increasingly being diagnosed in patients with systemic lupus erythematosus (SLE), and hydroxychloroquine (HCQ) has been found to possess antifungal activities. We hence aimed to investigate the association between HCQ and PCP risk among patients with SLE. METHODS:Using the 1997-2013 nationwide claim data, we identified 24,343 newly-diagnosed SLE patients. We then identified 58 PCP cases and selected 348 non-PCP controls matching (1:6) by age, sex, disease duration and the year of PCP diagnosis date. The risk of PCP was assessed by determing odds ratios (ORs) with 95% confidence intervals (CIs) by using multivariable conditional logistic regression. RESULTS:The risk of PCP was associated with moderate to severe renal disease (OR 6.73, 95% CI 1.98-2

SUBMITTER: Yeo KJ 

PROVIDER: S-EPMC7011312 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature