Magnetic liposome design for drug release systems responsive to super-low frequency alternating current magnetic field (AC MF).

ABSTRACT:

Hypothesis

Magnetic liposomes are shown to release the entrapped dye once modulated by low frequency AC MF. The mechanism and effectiveness of MF application should depend on lipid composition, magnetic nanoparticles (MNPs) properties, temperature and field parameters.

Experiments

The study was performed using liposomes of various lipid composition and embedded hydrophobic MNPs. The liposomes structural changes were studied by the transmission electron microscopy (TEM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and the leakage was monitored by the fluorescent dye release.

Findings

Magnetic liposomes exposure to the AC MF resulted in the clustering of the MNPs in the membranes and disruption of the lipid packaging. Addition of ch

SUBMITTER: Vlasova KY 

PROVIDER: S-EPMC7012191 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature