Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.

ABSTRACT: The contribution of autophagy to catabolic balance has been well-established in various types of cells, whereas the involvement of autophagy in progesterone synthesis during rat pregnancy still remains unknown. Therefore, the present study was designed to evaluate the role of autophagy in progesterone production during the luteal development of pregnant rats. The results showed autophagy-related proteins was maintained at a low level on day 10 after pregnancy, significantly induced on day 16 and subsided to a relative low level on day 21, which was consistent with the changes of serum progesterone levels. The findings further indicated the contribution of autophagy to progesterone production was regulated by inactivation of Akt/mTOR signaling during the luteal development of pregnant rats

SUBMITTER: Tang Z 

PROVIDER: S-EPMC7016947 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature