SYNPLA, a method to identify synapses displaying plasticity after learning.
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ABSTRACT:
SUBMITTER: Dore K
PROVIDER: S-EPMC7022215 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
SYNPLA, a method to identify synapses displaying plasticity after learning.
Dore Kim K Pao Yvonne Y Soria Lopez Jose J Aronson Sage S Zhan Huiqing H Ghosh Sanchari S Merrill Sabina S Zador Anthony M AM Malinow Roberto R Kebschull Justus M JM
Proceedings of the National Academy of Sciences of the United States of America 20200123 6
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synapt ...[more]
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