High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1.

ABSTRACT:

Objective

This research is aimed at investigating how high glucose affects the proliferation and apoptosis in periodontal ligament stem cells (PDLSCs) in the presence of TNF-α.

Methods

PDLSCs obtained from periodontal healthy permanent teeth were treated under either high-glucose condition (30 mmol/L, G30 group) or normal glucose condition (5.6 mmol/L, G5.6 group) in the presence or absence of TNF-α. α. α.

Results

CCK-8 assay showed that high glucose exacerbated TNF-α. α. α. α. α. α.

Conclusion

High glucose exacerbates TNF-α-induced proliferative inhibition in human periodontal ligament stem cells through the upregulation and activation of TNF receptor 1. Inhibition of intracellular RO

SUBMITTER: Zhu W 

PROVIDER: S-EPMC7025077 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature