Dataset Information

High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1.

ABSTRACT:

Objective

This research is aimed at investigating how high glucose affects the proliferation and apoptosis in periodontal ligament stem cells (PDLSCs) in the presence of TNF-α.

Methods

PDLSCs obtained from periodontal healthy permanent teeth were treated under either high-glucose condition (30 mmol/L, G30 group) or normal glucose condition (5.6 mmol/L, G5.6 group) in the presence or absence of TNF-α. α. α.

Results

CCK-8 assay showed that high glucose exacerbated TNF-α. α. α. α. α. α.

Conclusion

High glucose exacerbates TNF-α-induced proliferative inhibition in human periodontal ligament stem cells through the upregulation and activation of TNF receptor 1. Inhibition of intracellular ROS expression by vitamin C partially rescues PDLSCs in terms of cell proliferation.α.

SUBMITTER: Zhu W

PROVIDER: S-EPMC7025077 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

High Glucose Exacerbates TNF-<i>α</i>-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1.

Zhu Wenjun W Qiu Qihong Q Luo Haoyuan H Zhang Fuping F Wu Juan J Zhu Xiaorui X Liang Min M

Stem cells international 20200205

<h4>Objective</h4>This research is aimed at investigating how high glucose affects the proliferation and apoptosis in periodontal ligament stem cells (PDLSCs) in the presence of TNF-<i>α</i>.<h4>Methods</h4>PDLSCs obtained from periodontal healthy permanent teeth were treated under either high-glucose condition (30 mmol/L, G30 group) or normal glucose condition (5.6 mmol/L, G5.6 group) in the presence or absence of TNF-<i>α</i>. <i>α</i>. <i>α</i>.<h4>Results</h4>CCK-8 assay showed that high glu ...[more]

PMID: 32089705

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