ABCA7 Gene Expression and Genetic Association Study in Schizophrenia.

ABSTRACT:

Introduction

Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimer's disease, the relationship between ABCA7 and schizophrenia has been unknown.

Methods

Schizophrenia patients (n = 50; 24 males, 62.1 ± 0.50 years old) and age- and sex-matched healthy controls (n = 50) were recruited for the mRNA analysis. Additionally, a case-control study for the rs3764650 genotypes was performed with 1308 samples (control subjects; n = 527, schizophrenia patients; n = 781). All participants were Japanese, unrelated to each other, and living in the same area.

Results

The distributions of the rs3764650 genotypes in schizophrenia patients were not different from that of controls. However, the ABCA7 mRNA expression

SUBMITTER: Yamazaki K 

PROVIDER: S-EPMC7025661 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature