Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

ABSTRACT:

Objectives

To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care.

Methods

This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general practices were randomised equally to naproxen 750 mg immediately then 250 mg every 8 hours for 7 days or low-dose colchicine 500 mcg three times per day for 4 days. The primary outcome was change in worst pain intensity in the last 24 hours (0-10 Numeric Rating Scale) from baseline measured daily over the first 7 days: mean change from baseline was compared between groups over days 1-7 by intention to treat.

Results

Between 29 January 2014 and 31 December 2015, we recruited 399 participants (naproxen n=200, colchicine n=199), of wh

SUBMITTER: Roddy E 

PROVIDER: S-EPMC7025732 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature