Development and evaluation of a transfusion medicine genome wide genotyping array.

ABSTRACT:

Background

Many aspects of transfusion medicine are affected by genetics. Current single-nucleotide polymorphism (SNP) arrays are limited in the number of targets that can be interrogated and cannot detect all variation of interest. We designed a transfusion medicine array (TM-Array) for study of both common and rare transfusion-relevant variations in genetically diverse donor and recipient populations.

Study design and methods

The array was designed by conducting extensive bioinformatics mining and consulting experts to identify genes and genetic variation related to a wide range of transfusion medicine clinical relevant and research-related topics. Copy number polymorphisms were added in the alpha globin, beta globin, and Rh gene clusters.

Results

The final array co

SUBMITTER: Guo Y 

PROVIDER: S-EPMC7032526 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature