Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
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ABSTRACT:
SUBMITTER: Erlendsson S
PROVIDER: S-EPMC7032958 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Erlendsson Simon S Morado Dustin R DR Cullen Harrison B HB Feschotte Cedric C Shepherd Jason D JD Briggs John A G JAG
Nature neuroscience 20200106 2
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding t ...[more]
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