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Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome.

ABSTRACT:

Background

Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS.

Methods

In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay.

Results

There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls.

Conclusions

Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.

SUBMITTER: Hatami M

PROVIDER: S-EPMC7042409 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature

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Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome.

Hatami Maryam M Sobhan Mohammad Reza MR Dastgheib Seyed Alireza SA Jarahzadeh Mohammad Hossein MH Jafari Mohammadali M Yadegari Amirhossein A Sadeghizadeh-Yazdi Jalal J Neamatzadeh Hossein H

Journal of orthopaedics 20200113

<h4>Background</h4>Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS.<h4>Methods</h4>In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay.<h4>Results</h4>There were no significant differences in the allele and genotype ...[more]

PMID: 32127730

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