Over expression of METRN predicts poor clinical prognosis in colorectal cancer.

ABSTRACT:

Background

The role of meteorin (METRN) in colorectal cancer has not been reported previously. We aimed to explore the relationship between METRN and colorectal cancer (CRC) prognosis.

Methods

Data were retrieved from the Gene Expression Omnibus database. Gene expression values were log2 transformed and normalized by quantile normalization. Missing values were imputed with the R impute package. Differentially expressed genes were analyzed using the R limma package. METRN expression was compared between normal and CRC tissues and among different stages and subtypes of CRC. We assessed the relationship between METRN and KRAS/BRAF mutations in CRC. Five-year overall (OS), disease-free (DFS), and disease-specific survival (DSS) rates were determined by Kaplan-Meier analysis and

SUBMITTER: Xu X 

PROVIDER: S-EPMC7057108 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature