Identification of methylation states of DNA regions for Illumina methylation BeadChip.

ABSTRACT:

Background

Methylation of cytosine bases in DNA is a critical epigenetic mark in many eukaryotes and has also been implicated in the development and progression of normal and diseased cells. Therefore, profiling DNA methylation across the genome is vital to understanding the effects of epigenetic. In recent years the Illumina HumanMethylation450 (HM450K) and MethylationEPIC (EPIC) BeadChip have been widely used to profile DNA methylation in human samples. The methods to predict the methylation states of DNA regions based on microarray methylation datasets are critical to enable genome-wide analyses.

Result

We report a computational approach based on the two layers two-state hidden Markov model (HMM) to identify methylation states of single CpG site and DNA regions in HM450K

SUBMITTER: Luo X 

PROVIDER: S-EPMC7057447 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature