Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC7062825 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Experimental & molecular medicine 20200203 2
Isocitrate dehydrogenase 2 (IDH2) is an NADP<sup>+</sup>-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of mitochondrial reactive oxygen species (ROS). Here, we showed that high-fat diet (HFD) feeding resulted in accelerated weight gain in the IDH2KO mice due to a reduction in whole-body energy expenditure. Moreover, the levels of NADP<sup>+</sup>, NA ...[more]