Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8⁺ T cells of elderly mice.

ABSTRACT: Ca²⁺ is a crucial second messenger for proper T cell function. Considering the relevance of Ca²⁺ signals for T cell functionality it is surprising that no mechanistic insights into T cell Ca²⁺ signals from elderly individuals are reported. The main Ca²⁺ entry mechanism in T cells are STIM-activated Orai channels. Their role during lymphocyte aging is completely unknown. Here, we report not only reduced Ca²⁺ signals in untouched and stimulated, but also in central and effector memory CD8⁺ T cells from elderly (18-24 months) compared to adult (3-6 months) mice. Two mechanisms contribute to the overall reduction in Ca²⁺ signals of CD8⁺ T cells of elderly mice: 1) Reduced Ca²⁺ currents through Or

SUBMITTER: Angenendt A 

PROVIDER: S-EPMC7066920 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature