Endotoxin, food allergen sensitization, and food allergy: A complementary epidemiologic and experimental study.

ABSTRACT:

Background

Household endotoxin levels have been variably associated with risk for asthma and atopy.

Methods

We studied participants from the 2005-2006 National Health and Nutrition Examination Survey (NHANES, n = 6963), a large cohort representative of the US population (aged 1-84 years). We built logistic regression models to test for associations between house dust endotoxin and sensitization to specific foods (milk, egg, and peanut). To experimentally explore the detected epidemiologic associations, peripheral blood mononuclear cells (PBMCs) were collected from 21 children (aged 1-19 years) mono-food allergic (ie, sensitized and clinically reactive) to milk, egg, or peanut and nonallergic controls for stimulation with endotoxin and secreted cytokine measurement. For each

SUBMITTER: Tsuang A 

PROVIDER: S-EPMC7067651 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature