Rapid flow in multilayer microfluidic paper-based analytical devices.

ABSTRACT: Microfluidic paper-based analytical devices (μPADs) are a versatile and inexpensive point-of-care (POC) technology, but their widespread adoption has been limited by slow flow rates and the inability to carry out complex in field analytical measurements. In the present work, we investigate multilayer μPADs as a means to generate enhanced flow rates within self-pumping paper devices. Through optical and electrochemical measurements, the fluid dynamics are investigated and compared to established flow theories within μPADs. We demonstrate a ∼145-fold increase in flow rate (velocity = 1.56 cm s^-1, volumetric flow rate = 1.65 mL min^-1, over 5.5 cm) through precise control of the channel height in a 2 layer paper device, as compared to archetypical 1 layer μPAD designs. Th

SUBMITTER: Channon RB 

PROVIDER: S-EPMC7071557 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature