Age-related cognitive decline in myotonic dystrophy type 1: An 11-year longitudinal follow-up study.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is an inherited multi-systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this cognitive profile progresses over time is still a matter of debate. The aim of this study was to longitudinally assess a DM1 sample, in order to compare, for the first time, this progression with that of a control group. Clinical and socio-demographic predictive factors potentially implicated in this possible decline are analysed.

Method

Seventy-five DM1 patients with childhood, juvenile, adult, and late-onset, and 54 control participants were re-assessed in an 11-year follow-up with a comprehensive neuropsychological battery. The analyses employed were mixed A

SUBMITTER: Labayru G 

PROVIDER: S-EPMC7078919 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature