Ribitol enhances matriglycan of α-dystroglycan in breast cancer cells without affecting cell growth.

ABSTRACT: The laminin-binding glycan (matriglycan) on α-dystroglycan (α-DG) enables diverse roles, from neuronal development to muscle integrity. Reduction or loss of matriglycan has also been implicated in cancer development and metastasis, and specifically associated with high-grade tumors and poor prognoses in breast cancers. Hyperglycosylation of α-DG with LARGE overexpression is shown to inhibit cancer cell growth and tumorigenicity. We recently demonstrated that ribitol, considered to be a metabolic end-product, enhances matriglycan expression in dystrophic muscles in vivo. In the current study, we tested the hypothesis that ribitol could also enhance matriglycan expression in cancer cells. Our results showed for the first time that ribitol is able to significantly enhance the expression of ma

SUBMITTER: Lu PJ 

PROVIDER: S-EPMC7080755 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature