Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer.

ABSTRACT:

Background

Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific regulatory regions. Yet, it is not clear how these methylation changes compare across CAFs from different patients. Therefore, we examined the consistency and prognostic significance of genome-wide DNA methylation profiles between CAFs from patients with different grades of primary prostate cancer.

Results

We used Infinium MethylationEPIC BeadChips to evaluate genome-wide DNA methylation profiles from 18 matched CAFs and non-malignant prostate tissue fibroblasts (NPFs) from men with

SUBMITTER: Lawrence MG 

PROVIDER: S-EPMC7081708 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature