Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC7098802 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
JCI insight 20200213 3
Chronic alcohol abuse has a detrimental effect on the brain and liver. There is no effective treatment for these patients, and the mechanism underlying alcohol addiction and consequent alcohol-induced damage of the liver/brain axis remains unresolved. We compared experimental models of alcoholic liver disease (ALD) and alcohol dependence in mice and demonstrated that genetic ablation of IL-17 receptor A (IL-17ra-/-) or pharmacological blockade of IL-17 signaling effectively suppressed the increa ...[more]