Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics.

ABSTRACT: Voltage-gated sodium (Na _v ) channels form the basis for the initiation of the action potential in excitable cells by allowing sodium ions to pass through the cell membrane. The Na _v channel α subunit is known to function both with and without associated β subunits. There is increasing evidence that these β subunits have multiple roles that include not only influencing the voltage-dependent gating but also the ability to alter the spatial distribution of the pore-forming α subunit. Recent structural data has shown possible ways in which β1 subunits may interact with the α subunit. However, the position of the β1 subunit would not be compatible with a previous trimer structure of the β3 subunit. Furthermore, little is currently known about the dynamic beh

SUBMITTER: Glass WG 

PROVIDER: S-EPMC7103644 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature