Low sun exposure increases multiple sclerosis risk both directly and indirectly.

ABSTRACT:

Objective

We aimed to study (1) to what extent the influence of low sun exposure on multiple sclerosis (MS) risk is mediated by low vitamin D levels; (2) whether low sun exposure or vitamin D deficiency act synergistically with HLA-DRB1*15:01 and absence of HLA-A*02:01.

Methods

We used two population-based case-control studies (7069 cases, 6632 matched controls). Subjects with different HLA alleles, sun exposure habits and vitamin D status were compared regarding MS risk, by calculating odds ratios (OR) with 95% confidence intervals (CI) employing logistic regression. Mediation analysis was used to identify the potential mediation effect of vitamin D on the relationship between low sun exposure and MS risk.

Results

Low sun exposure increased MS risk directly as well a

SUBMITTER: Hedstrom AK 

PROVIDER: S-EPMC7109160 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature