Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo.

ABSTRACT: Long-lasting, latently infected resting CD4⁺ T cells are the greatest obstacle to obtaining a cure for HIV infection, as these cells can persist despite decades of treatment with antiretroviral therapy (ART). Estimates indicate that more than 70 years of continuous, fully suppressive ART are needed to eliminate the HIV reservoir¹. Alternatively, induction of HIV from its latent state could accelerate the decrease in the reservoir, thus reducing the time to eradication. Previous attempts to reactivate latent HIV in preclinical animal models and in clinical trials have measured HIV induction in the peripheral blood with minimal focus on tissue reservoirs and have had limited effect^2-9. Here we show that activation of the non-canonical NF-κB signalling pathway

SUBMITTER: Nixon CC 

PROVIDER: S-EPMC7111210 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature