Suppressive activity of Vδ2⁺ γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength.

ABSTRACT: Despite recent progress in the understanding of γδ T cells' roles and functions, their interaction with αβ T cells still remains to be elucidated. In this study, we sought to clarify what precisely endows peripheral Vδ2⁺ T cells with immunosuppressive function on autologous αβ T cells. We found that negatively freshly isolated Vδ2⁺ T cells do not exhibit suppressive behavior, even after stimulation with IL-12/IL-18/IL-15 or the sheer contact with butyrophilin-3A1-expressing tumor cell lines (U251 or SK-Mel-28). On the other hand, Vδ2⁺ T cells positively isolated through TCR crosslinking or after prolonged stimulation with isopentenyl pyrophosphate (IPP) mediate strong inhibitory effects on αβ T cell proliferation. Stimulation with IPP in the presence of IL-

SUBMITTER: Schilbach K 

PROVIDER: S-EPMC7113223 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature