An improved de novo genome assembly of the common marmoset genome yields improved contiguity and increased mapping rates of sequence data.

ABSTRACT:

Background

The common marmoset (Callithrix jacchus) is one of the most studied primate model organisms. However, the marmoset genomes available in the public databases are highly fragmented and filled with sequence gaps, hindering research advances related to marmoset genomics and transcriptomics.

Results

Here we utilize single-molecule, long-read sequence data to improve and update the existing genome assembly and report a near-complete genome of the common marmoset. The assembly is of 2.79 Gb size, with a contig N50 length of 6.37 Mb and a chromosomal scaffold N50 length of 143.91 Mb, representing the most contiguous and high-quality marmoset genome up to date. Approximately 90% of the assembled genome was represented in contigs longer than 1 Mb, with approximately 104-fol

SUBMITTER: Jayakumar V 

PROVIDER: S-EPMC7114785 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature