Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry.

ABSTRACT: Systemic mastocytosis (SM) is frequently associated with eosinophilia. To examine its prevalence and clinical impact in all WHO classification-based subcategories, we analyzed eosinophil counts in 2350 mastocytosis patients using the dataset of the European Competence Network on Mastocytosis. Ninety percent of patients had normal eosinophil counts, 6.8% mild eosinophilia (0.5-1.5 × 10⁹/l), and 3.1% hypereosinophilia (HE; >1.5 × 10⁹/l). Eosinophilia/HE were mainly present in patients with advanced SM (17%/19%), and only rarely recorded in patients with indolent and smoldering SM (5%/1%), and some patients with cutaneous mastocytosis. The eosinophil count correlated with organomegaly, dysmyelopoiesis, and the WHO classification, but not with mediator-related symptoms or

SUBMITTER: Kluin-Nelemans HC 

PROVIDER: S-EPMC7115841 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature