Fixation of Hydrogel Constructs for Cartilage Repair in the Equine Model: A Challenging Issue.

ABSTRACT:

Objective

To report on the experiences with the use of commercial and autologous fibrin glue (AFG) and of an alternative method based on a 3D-printed polycaprolactone (PCL) anchor for the fixation of hydrogel-based scaffolds in an equine model for cartilage repair.

Methods

In a first study, three different hydrogel-based materials were orthotopically implanted in nine horses for 1-4 weeks in 6 mm diameter full-thickness cartilage defects in the medial femoral trochlear ridge and fixated with commercially available fibrin glue (CFG). One defect was filled with CFG only as a control. In a second study, CFG and AFG were compared in an ectopic equine model. The third study compared the efficacy of AFG and a 3D-printed PCL-based osteal anchor for fixation of PCL-reinforced hydrog

SUBMITTER: Mancini IAD 

PROVIDER: S-EPMC7116030 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature