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Mechanisms and significance of Ca²⁺ entry through TRPC channels.

ABSTRACT: The transient receptor potential (TRP) superfamily of plasma membrane cation channels has been recognized as a signaling hub in highly diverse settings of human physiopathology. In the past three decades of TRP research, attention was focused mainly on the channels Ca²⁺ signaling function, albeit additional cellular functions, aside of providing a Ca²⁺ entry pathway, have been identified. Our understanding of Ca²⁺ signaling by TRP proteins has recently been advanced by a gain in high-resolution structure information on these pore complexes, and by the development of novel tools to investigate their role in spatiotemporal Ca²⁺ handling. This review summarizes recent discoveries as well as remaining, unresolved aspects of the canonical subfamily of transient receptor potential channels (TRPC) research. We aim at a concise overview on current mechanistic concepts of Ca²⁺ entry through- and Ca²⁺ signaling by TRPC channels.

SUBMITTER: Bacsa B

PROVIDER: S-EPMC7116371 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Mechanisms and significance of Ca2+ entry through TRPC channels.

Bacsa Bernadett B Tiapko Oleksandra O Stockner Thomas T Groschner Klaus K

Current opinion in physiology 20200629

The transient receptor potential (TRP) superfamily of plasma membrane cation channels has been recognized as a signaling hub in highly diverse settings of human physiopathology. In the past three decades of TRP research, attention was focused mainly on the channels Ca2+ signaling function, albeit additional cellular functions, aside of providing a Ca2+ entry pathway, have been identified. Our understanding of Ca2+ signaling by TRP proteins has recently been advan ...[more]

PMID: 33210055

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