Ontology highlight
ABSTRACT:
SUBMITTER: Sakae Y
PROVIDER: S-EPMC7132775 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Biology open 20200407 4
The teleost fish, medaka (<i>Oryzias latipes</i>), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal. Metabolomic and RT-qPCR analyses indicated that pantothenate metabolism was suppressed by starvation. Consistently, inhibiting the pantothenate metabolic pathway caused sex reversal. The final metabolite in this pathway ...[more]