Ontology highlight
ABSTRACT:
SUBMITTER: Sarcinelli C
PROVIDER: S-EPMC7139862 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Sarcinelli Carmen C Dragic Helena H Piecyk Marie M Barbet Virginie V Duret Cédric C Barthelaix Audrey A Ferraro-Peyret Carole C Fauvre Joelle J Renno Toufic T Chaveroux Cédric C Manié Serge N SN
Cancers 20200301 3
Endoplasmic reticulum (ER) stress generates reactive oxygen species (ROS) that induce apoptosis if left unabated. To limit oxidative insults, the ER stress PKR-like endoplasmic reticulum Kinase (PERK) has been reported to phosphorylate and activate nuclear factor erythroid 2-related factor 2 (NRF2). Here, we uncover an alternative mechanism for PERK-mediated NRF2 regulation in human cells that does not require direct phosphorylation. We show that the activation of the PERK pathway rapidly stimul ...[more]